ProtoEase – Natural Support for Horses with EPM

5.00 out of 5
(2 customer reviews)


Buy 3 or more Signature Line Organic Herbal Formulas and save 5%

EPM (Equine Protozoal Myeloencephalitis) is a degenerative, neurological disease produced by an intracellular parasite, protozoa S. neurona, which is transferred to horses via Opossum droppings. More than 50 percent (and in some areas as high as 90%) of horses in the United States may have been exposed to the organism that causes EPM. Fortunately, only a very small percentage of horses which have been exposed to this organism will ever develop the disease we call EPM.

Our herbal formula contains herbs with anti-inflammatory, immune-boosting, anti-protozoal, calming, stress-reducing, analgesic and detoxifying properties. Also promotes lymphatic cleansing and muscle function.

750 grams (Approx. 1 lb. 10.5 oz.) Approximately 60 one scoop servings per jar. Refer to dosage tab below for more information. Our Signature Line includes free shipping. If other products are ordered at the same time, shipping charges will apply to those items. In order to receive free shipping on this product, it must be ordered by itself.

Quantity discounts - Buy more and save!
1-2 $135.00
3+ $128.25

Product Description

Equine Wellness Approved Signature Line - HighRes-2016

Our Signature Line Organic Herbal Formulas were created exclusively for The Holistic Horse by a leading equine veterinarian specializing in endocrinology, herbs and nutrition.

Nature has provided us with a variety of wonderful healing herbs which we have custom blended to benefit your horse’s health.

These amazing formulas contain the very finest certified organic herbs. They are handcrafted and mixed in small batches to ensure freshness and quality. We freshly grind many of our herbs upon order. They are also non-GMO, without fillers and are free of sugar and non-structural carbohydrates (NSC). Therefore these formulas are suitable to feed to horses with IR/Metabolic issues.

While other companies may offer similar products, many of their herbs are not organic. Our formulas also have a much higher concentration of herbs per dose ensuring greater effectiveness. They also contain unique herbs not found in other products.

EPM is NOT transmitted from horse to horse. Why one horse gets EPM from opossum droppings and another one does not, is unknown. One of the widely acknowledged factors seems to be a weakened immune system. Therefore, whether preventatively or complimentary alongside or after drug treatment, supporting the equine immune system is essential in the recovery of horses with EPM. Pau D‘ Arco has shown to be a powerful herb to boost the immune system while at same time having anti-protozoal properties. Eleuthero is an immune stimulant and adaptogenic (see below).

The dramatic overall symptoms produce additional stress on the body which in return can weaken the immune system more. Breaking this downward stress spiral can dramatically help a horse with EPM. Adaptogenic (stress-reducing) herbs such as Eleuthero (Siberian Ginseng) have shown to be powerful remedies.

While nothing will remove the protozoa from the body, we can try to reduce its impact. The disease is a master in disguise and symptoms can be very unspecific. They usually include neurological problems, ataxia and muscular-skeletal soreness. Calming and supporting the nervous system in a horse with EPM can help the horse cope during the recovery process much better. Lemon Balm has a soothing effect on the central nervous system and the gastrointestinal tract. It will reduce anxiety and agitation. Furthermore, it has the added effect of anti-spasmodic properties helping to reduce signs of mild colic, muscle pain, cramping and twitching.

In a horse infected with EPM, the whole body suffers from inflammation and pain. Herbs with anti-inflammatory and analgesic properties can help significantly. White Willow Bark (Salix Alba) has anti-inflammatory and analgesic properties. It is ideal to battle signs resembling muscle- and joint pain, rheumatism, fever, colic and cramps.

The body might get overwhelmed trying to eliminate toxic waste produced by the infection. It is essential to support liver function (Dandelion Leaf, Milk Thistle) and the lymphatic system in particular to detoxify from the parasitic toxins as well as from drug metabolites (Cleavers, Calendula). Cleavers is also very high in Vitamin C, which helps the immune system.

Anise and Stevia are added to enhance palatability. Stevia serves as a natural, sugar-free sweetener. Anise is also an appetite stimulant.


EPM and any health challenges resembling EPM require a truly multi-factorial holistic approach for feeding and management. The following are recommendations from our staff Veterinarian and Nutritionist:

  • Provide ample clean water. If you prefer Automatic water feeders, make sure they hold at least a gallon of water.
  • Add 2-4 tablespoons of sea salt per day to your horses feed. We offer “Pure Unrefined Sea Salt“.
  • The main reason for EPM infections is believed to be a weakened immune system. Strengthen your horses immune system with our “Vyrex” or “ImmunoBoost“.
  • Your horse might have an increased need for full spectrum amino acids to protect and re-build muscle tissue. Therefore you might consider feeding a 30-percent protein ration balancer (Two pounds per 1,000 horse daily).
  • The stress produced by disease increases the need for minerals and vitamins. Consider adding our “Organic Icelandic Kelp” to your horses diet.

Have patience! Picky eaters can be a challenge. Go slow and easy and work on convincing your horse the herbs are good for them!

Healing Herbs and their beneficial properties:

Organic Pau d‘Arco Bark: Made from the bark of a large evergreen tropical tree found in Latin America and South America, this herb is a potent antiparasitic remedy. It also has antimicrobial, antiviral, antibacterial, antifungal and anti-inflammatory properties, as well as analgesic, antioxidant, astringent effects. Many of its benefits have been traced back to blood-cleansing compounds and compounds that inhibit harmful microorganisms.

Organic Eleuthero Root: Also known as Siberian ginseng, Eleuthero is an adaptogen, which means it helps the body adapt to stress by acting on the adrenals and mediating your body’s stress response. It also helps increase endurance, to reduce fatigue, and boost immunity. This herb acts as a general neuroprotective for neurodegenerative disorders and helps increase mental sharpness.

Organic Lemon Balm Leaf: Eases stress and anxiety. Lemon balm contains a compound known as rosmarinic acid which has potent antioxidant, antimicrobial and anti inflammatory properties. Helps strengthen the immune system and enhances cognitive function.

Organic White Willow Bark: Considered by many to be a “natural aspirin” and nerve sedative without the side effects of pharmaceutical drugs. Also contains anti inflammatory, antiseptic and antispasmodic properties.

Organic Dandelion Leaf: Studies also show that dandelion boosts immune function and fights off microbes and fungi. Dandelion contains essential fatty acids, antioxidants, and phytonutrients that all reduce inflammation throughout the body. Dandelion leaf helps prevent oxidative stress, inflammation and damage to the liver. Dandelion acts as a mild laxative that promotes digestion, stimulates appetite, and balances the natural and beneficial bacteria in the intestines. It can increase the release of stomach acid and bile to aid digestion, especially of fats.

Organic Milk Thistle Seed: Improves cognition and boosts the immune system. It Supports liver health. The active ingredient in milk thistle, silymarin, acts as an antioxidant by reducing free radical production. Scientists believe this creates a detoxifying effect, which is why it is milk thistle is beneficial for liver problems. A study found milk thistle extract helped to reduce insulin resistance.

Organic Cleavers Herb: Cleaver is known as a lymphatic healer it cleanses and tones the lymph, relieves swollen glands. Cleaver herb also acts as a diuretic flushing and decongesting to the kidneys and urinary system. It also aids in cystitis and water retention. Acts as a blood cleanser to help purify and detoxify the blood.

Organic Calendula Flower: Calendula has been found to have strong anti-inflammatory properties via powerful flavonoids. Calendula can help prevent and relax muscle spasms. This flower also contains Antimicrobial & Antiviral Components The oils and acids within the plant have shown to be effective in fighting pathogens, as well as candida symptoms and even antibiotic resistant strains of bacteria!

Organic Anise: Effective natural expectorant – relieves congestion and coughing, digestive aid, anti inflammatory.

Organic Stevia: A natural sweetener, anti bacterial, anti oxidant, promotes proper digestion, contains potassium zinc, magnesium and vitamin B3.


The Holistic Horse recommends that you consult with your veterinarian if any adverse changes occur in your horse while using our products or if you have specific health issues or concerns regarding your horse. Owner accepts all responsibility while using these products. These statements have not been evaluated by the Food and Drug Administration. The information provided is for educational purposes only and is not intended to diagnose, treat, cure or prevent any disease.

Shake container before using.

This formula can be given alongside your Veterinarians treatment and/or as a long term supplement to reduce the risk of recurrence of EPM or EPM-like signs.

Dosing: The following recommendations apply for a 1,000 lbs horse. For horses higher or lower in weight, adjust amounts accordingly.
Phase 1 Loading: When acute signs of EPM or EPM-like signs are present, we recommend to give 5 scoops daily for three days.
Phase 2 Maintenance: After three days, reduce amount to 2 1/2 scoops daily while any signs persist.
Phase 3 Long-term risk reduction and support: When no signs of EPM or EPM like signs are present, keep horse on 1 scoop daily.

Note: Dosing with herbs is different than dosing with medication. Herbs have a much wider safety margin regarding the amounts that can be fed and each horse is differently susceptible.

NOTE: Do not use on pregnant or lactating mares.

Store in a dry, cool and dark place.

2 reviews for ProtoEase – Natural Support for Horses with EPM

  1. 5 out of 5

    Julie Hembrough (verified owner)

    Feb. 27th my husband and I noticed that our 5 yr old mare was struggling to walk and was obviously in pain. We had never heard of EPM, but the veterinarian diagnosed her 2 days later. He put her on a 14 day medication treatment. For years the natural holistic approach to health, has been a way of life for me. During the first few days of her treatment I was searching frantically for a quality, safe, natural holistic approach to build her immune system because I understood that the (much needed) aggressive medication would further compromise her weakened immune system; when I came across this website I knew that I had found what I was looking for!!! We ordered the ProtoEase and without delay they rushed it out! Soon after I ordered their other products that would help support and build her immune system. Due to what the vet had told us we were so surprised to see such a quick improvement! Because she was not able to get up on her own, my husband and I had to take turns watching her at night to make sure that she didn’t lie down too long and to help her up. After 7 weeks now she can get up on her own and prance like a deer! We’re thoroughly convinced these products have saved her life! We thank God for The Holistic Horse and their quality products!

    Julie H.

  2. 5 out of 5

    Paula Speicher (verified owner)

    My 21 year old gelding started having problems controlling his rear legs. He would fall down and have difficulty getting up. My vet diagnosed him with EPM and he was started on Marquis and Rebalance. He made some improvement , but I was hoping for a better recovery . I was terrified that I might lose him to this horrible disease. I began to search for other treatment plans and thankfully found The Holistic Horse. I purchased the Proto Ease, and a few of the other recommended supplements, and within a couple of weeks, there was a huge improvement in his mobility. After I finished my container of Proto Ease, he was doing so well that I did not reorder a second container. Shortly after that, his condition started to deteriorate. I realized that the only thing different was that I was no longer giving him the Proto Ease . I purchased it and started him back on it, and the results were astounding! He is now almost completely sound. I have even been able to ride him at a walk in the arena. When the vet came out for a recheck, she was amazed at how much he had improved. I told her about The Holistic Horse, so that other people could use it to treat their horses who suffer from EPM. I am so grateful that I found this product. I will continue to keep him on it, so he stays in optimal health.
    Paula S.

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